I troubleshooted this for a while and initially thought it was a permissions issue with my install. For whatever reason, I am unable to add, clone, rename, or remove presets if I have the Migaku Anki addon enabled. I've isolated this by disabling every addon I have one by one. If I disable the addon, do whatever I need to do for the presets (add/clone/whatever) and then reenable it everything works fine.
This is on Anki 2.1.49 on Windows 11. I have also deleted the addon and reinstalled to no avail. Let me know if you need any more info!